Bell DS, Harvard Medical School, Boston, Massachusetts.
A number of abnormalities found in patients with chronic fatigue syndrome point to central nervous system (CNS) involvement.
These include immunologic abnormalities, indications of pituitary and hypothalamic involvement, abnormal basal plasma levels of certain neurotransmitter metabolites, and cerebral perfusion abnormalities.
The possibility that a novel human retrovirus may be present in patients with the syndrome needs further study.
PS: Publication from 1994 !!!