Monday, March 2, 2015

Scientists Successfully Remove HIV From Human Cells

BY Dan Avery:

  "Researchers at Temple University in Philadelphia have been able to destroy HIV in human cells, rather than simply suppress it, a breakthrough in the ongoing fight against HIV/AIDS.

  “It’s an important finding because, for the first time in laboratory setting, we show that the virus can be eradicated from human culture, cell culture, said Dr. Kamel Khalili, who led the research team at Temple’s Center for Neurovirology.

  “Basically [we're] converting infected cells to un-infected cells,” he explains “And that is very important because the current therapy can not eliminate the virus from cells.”

  Dr. Khalili’s team developed molecular tools that can operate on DNA and delete HIV in cells."

  more

Sunday, March 1, 2015

The NewYorker: People with ME/CFS are more “functionally impaired” than those with MS and congestive heart failure

BY MEGHAN O’ROURKE, FEBRUARY 27, 2015:

  "People with ME/CFS, the report noted, are more “functionally impaired” than those with Type 2 diabetes, multiple sclerosis, and congestive heart failure—diseases that we know to be very grave indeed."

  more @ newyorker.com

Saturday, February 28, 2015

Psychiatrists commenting on immunological abnormalities, typical science media Center crap

By Utting Wolff:

  "The Science Media Centre surpassed itself in its coverage of the Columbia University study[6]. Of seven experts chosen to respond to the study, not one gives a positive analysis, no medical adviser from an ME charity or, non-psychosomatic promoting, ME researcher is quoted.

  The featured experts are: Professors Michael Sharpe and Peter White, and Dr Esther Crawley, all notorious proponents of the psychogenic ME model.

  Professor Stephen Lawrie, head of The Division of Psychiatry at the University of Edinburgh: ‘This is a small study’ he states[6]; a study encompassing 20 participants is small professor Lawrie, one involving over 600 participants is not[1]. One has to ask why is a psychiatrist being consulted?"

Thursday, February 26, 2015

IOM: ME/CFS "is a medical—not a psychiatric or psychological—illness"

@ PubMed:

 

Beyond Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Redefining an Illness.

Editors

Committee on the Diagnostic Criteria for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome; Board on the Health of Select Populations; Institute of Medicine.

Source

Excerpt

Myalgic encephalomyelitis (ME) and chronic fatigue syndrome (CFS) are serious, debilitating conditions that affect millions of people in the United States and around the world. ME/CFS can cause significant impairment and disability. Despite substantial efforts by researchers to better understand ME/CFS, there is no known cause or effective treatment. Diagnosing the disease remains a challenge, and patients often struggle with their illness for years before an identification is made. Some health care providers have been skeptical about the serious physiological—rather than psychological—nature of the illness. Once diagnosed, patients often complain of receiving hostility from their health care provider as well as being subjected to treatment strategies that exacerbate their symptoms. 

Beyond Myalgic Encephalomyelitis/Chronic Fatigue Syndrome proposes new diagnostic clinical criteria for ME/CFS and a new term for the illness - systemic exertion intolerance disease(SEID). According to this report, the term myalgic encephalomyelitis does not accurately describe this illness, and the term chronic fatigue syndrome can result in trivialization and stigmatization for patients afflicted with this illness. Beyond Myalgic Encephalomyelitis/Chronic Fatigue Syndrome stresses that SEID is a medical—not a psychiatric or psychological—illness. This report lists the major symptoms of SEID and recommends a diagnostic process. One of the report's most important conclusions is that a thorough history, physical examination, and targeted work-up are necessary and often sufficient for diagnosis. 

The new criteria will allow a large percentage of undiagnosed patients to receive an accurate diagnosis and appropriate care. Beyond Myalgic Encephalomyelitis/Chronic Fatigue Syndrome will be a valuable resource to promote the prompt diagnosis of patients with this complex, multisystem, and often devastating disorder; enhance public understanding; and provide a firm foundation for future improvements in diagnosis and treatment.
Copyright © 2015, National Academy of Sciences.

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    Free Books & DocumentsFree full text

    Tuesday, February 24, 2015

    The real reason why Prof Edward Shorter is ridiculing and attacking severely ill patients

    So why did professor Edward Shorter write his 2 very aggressive / hostile / vile articles in psychologytoday, attacking patients who are severely ill?

      Even though he is a psychiatrist and a medical historian, he shows a total lack of knowledge about basic facts about this disease and totally ignores all clinical evidence etc that what he says is total rubbish / nonsense.

      The answer to the question can be found in one of his tweets, ie his new book is out on the 7th of march.

      @DrEdwardShorter: "amazon.com/What-Psychiatr… The pub date for this is Mar 7 but Amazon up now. Theme: what should have been in but wasn't and shouldn't but was."

      So all he cares about is selling books, earning money and getting his name in the paper, that he has to ridicule and attack severe ill patients to do so, is obviously no problem to him or to psychologytoday.

      And that's the sad state of affairs of psychiatry and psychology in 2015.

      See also Prof Edward Shorter and the psychic epidemic of ignoring clinical evidence

     

    Monday, February 23, 2015

    Prof Edward Shorter and the psychic epidemic of ignoring clinical evidence

    A phenomenon well familiar to historians of medicine is the psychic epidemic of ignoring clinical evidence by psychiatrists and medical historians, a belief that spreads epidemically, until the evidence become so overwhelming that it becomes clear that these people have been telling porkies for decades, and then their nonsense is forgotten.

      In the 20th century, psychiatry fostered such an epidemic with the belief that ego masturbation caused their bank accounts to inflate. Many medical historians and psychiatrists obsessed for years over the thought that their “self-abuse” had pleased their bank managers.

      Another epidemic focused on the toxic  effects of ignoring clinical evidence on the ovaries. Many male medical historians and male psychiatrists would plead for ovariectomies, on the grounds that their irritated ovaries were blocking clinical evidence which their penis had spotted, to go all the way to their brain. And that this was leading to erectile dysfunction and the inability to have an orgasm.

      Once their ovaries were removed, their penis size increased by more than 5 inches. So all these male medical historians and male psychiatrists were pleading their doctors for ovariectomies.

      In the late 1980s the belief spread epidemically that reading clinical evidence caused irreversible brain damage, and a number of leading medical historians and psychiatrists wrote books full of advice about eating small meals upside down, with your eyes closed and your brain in hibernation mode, to make sure that clinical evidence would not reach your brain to prevent brain damage.

      I realize that these words will fall unreceptively upon some ears, and I regret that some medical historians and psychiatrists, especially from Toronto, may feel slighted by the clinical evidence that is readily available, if only they where willing to turn on their computer and were willing to read biomedical research, for example the fMRI studies from Stanford, or the PET scan study from Japan. 

      Yet there are larger stakes here. In the way that lives were once ruined with such toxic diagnoses as hysteria, which in this day and age is called MS, millions of lives today are ruined by medical historians and pinocchio psychiatrists who have made a fortune out of ignoring clinical evidence.

      Many psychiatrists and medical historians choose their profession so that they didn't have to become productive members of the community.  (The IOM report dwelled upon the dangers of severely ill patients being abused by the medical profession.) 

      Such a waste of human potential is tragic, and if there are lessons that we may draw from the history of medicine, it is that doctors who discover the underlying metabolic problem or cause of such diseases, which medical historians and psychiatrists call psychosomatic, even though they do not have any evidence to back up this claim, will go on to win the Nobel prize for medicine, as the Nobel Prize winner in medicine, Dr Barry Marshall stated a few years ago.

    Friday, February 20, 2015

    Social sciences lecturer Angela Kennedy: Psychogenic explanations for physical illnesses are almost always fatally flawed

    @ amazon.co.uk:

    Since the advent of "medicine" as a discrete practice, beliefs that bodily illness can somehow be caused by psychological, emotional, and behavioural "disorder" have been claimed by many in the discipline. Such beliefs became less creditable as scientific methods of detecting disease developed, with discoveries such as the physiological and anatomical abnormalities in Parkinson's disease and Multiple Sclerosis, for example, and the organisms causing syphilis and duodenal ulcers.

      Nevertheless, psychogenic explanations for illnesses still appear frequently within medical and academic literature, in "common sense" public discourses, and in medical diagnoses of patients. But how plausible are these explanations? Authors of our Own Misfortune? proposes that psychogenic explanations for physical illnesses are subject to a complex mix of confusing concepts, accompanied by certain moralistic and ideological assumptions about people and their illnesses.

      Most crucially, such explanations are also, almost always, fatally flawed, both scientifically and logically.

      Furthermore, the widespread, uncritical acceptance and use of such explanations has had serious and specific adverse effects on the people upon whom they are used.

      This is a timely, groundbreaking book about a critical theme in medicine. It provides rigorous analysis of the claims made about "mental disorder" and bodily illness, using current "medical controversies" (such as, but not limited to, Myalgic Encephalomyelitis and Chronic Fatigue Syndrome) to demonstrate the problems with and adverse effects of such claims. Authors of our Own Misfortune? is essential reading for academics, health professionals, and those directly or indirectly affected by psychogenic explanations for illness.

      Angela Kennedy is a social sciences lecturer and researcher at a number of universities in London, and author of numerous articles, papers and books in lay, professional and academic media over a 30 year career.

      Her academic research interests include: the social stratification, scapegoating and social exclusion of disadvantaged groups, and the effects of these; constructions of moral panics; and the sociology of science and medicine, including manifestations of the 'science wars'.

    Monday, February 16, 2015

    The denial of this illness by doctors means that patients are suffering slow, horrific deaths

    By Kristy Muir, 13th February 2015 :

      "The 37-year-old Bribie Island woman is in the fight of her life against a debilitating disease and consequential infections.

      In February 2013 Amara was diagnosed with Lyme disease (borrelia), bartonella, babesia and multiple other infections.

      Prior to that she suffered chronic fatigue syndrome, diagnosed when she was 23. Amara's condition means she suffers severe seizures daily, as well as photophobia (sensitivity to light), severe cramps and muscle spasms."

      ##########

      ""Amara is desperately unwell with late (stage) neurological Lyme disease," Ms Collingwood said.

      "What makes her illness different is that the medical profession do not recognise Lyme disease in Australia, despite the fact that thousands of Australians have tested positive to Lyme (via testing facilities in overseas labs) and the numbers are only continuing to increase.

      "The denial of this illness in Australia by the health fraternity means that there is very little to no treatment available here.

      "People are suffering slow, horrific deaths and it is completely unnecessary.""

    Saturday, February 14, 2015

    The Guardian: ME/CFS, a serious disease dismissed as laziness says The Institute of Medicine

    The Guardian, 13 February 2015:

      "People often dismiss sufferers of chronic fatigue syndrome as lazy because the seriousness of the disease is not understood."

    ###########


    • "“Having called this serious disease by an inappropriate and frankly insulting name is one of the factors that kept doctors, friends, family members, even employers from affording it the seriousness it deserves,” she said."

    Friday, February 13, 2015

    The causative role of alum adjuvant in vaccines in slow brain translocation and delayed neurotoxicity in ME/CFS

    Front. Neurol., 05 February 2015; FULL article @ journal.frontiersin.org:
    REVIEW ARTICLE Biopersistence and brain translocation of aluminum adjuvants of vaccinesimageRomain Kroum Gherardi* , imageHousam Eidi, imageGuillemette Crépeaux, imageFrançois Jerome Authier  and imageJosette Cadusseau * Faculté de Médecine and Faculté des Sciences et Technologie, INSERM U955 Team 10, Université Paris Est-Créteil, Créteil, France Aluminum oxyhydroxide (alum) is a crystalline compound widely used as an immunological adjuvant of vaccines. Concerns linked to the use of alum particles emerged following recognition of their causative role in the so-called macrophagic myofasciitis (MMF) lesion detected in patients with myalgic encephalomyelitis/chronic fatigue/syndrome. MMF revealed an unexpectedly long-lasting biopersistence of alum within immune cells in presumably susceptible individuals, stressing the previous fundamental misconception of its biodisposition. We previously showed that poorly biodegradable aluminum-coated particles injected into muscle are promptly phagocytosed in muscle and the draining lymph nodes, and can disseminate within phagocytic cells throughout the body and slowly accumulate in brain. This strongly suggests that long-term adjuvant biopersistence within phagocytic cells is a prerequisite for slow brain translocation and delayed neurotoxicity. The understanding of basic mechanisms of particle biopersistence and brain translocation represents a major health challenge, since it could help to define susceptibility factors to develop chronic neurotoxic damage. Biopersistence of alum may be linked to its lysosome-destabilizing effect, which is likely due to direct crystal-induced rupture of phagolysosomal membranes. Macrophages that continuously perceive foreign particles in their cytosol will likely reiterate, with variable interindividual efficiency, a dedicated form of autophagy (xenophagy) until they dispose of alien materials. Successful compartmentalization of particles within double membrane autophagosomes and subsequent fusion with repaired and re-acidified lysosomes will expose alum to lysosomal acidic pH, the sole factor that can solubilize alum particles. Brain translocation of alum particles is linked to a Trojan horse mechanism previously described for infectious particles (HIV, HCV), that obeys to CCL2, signaling the major inflammatory monocyte chemoattractant. Billions of humans have been vaccinated and marked regression or eradication of several severe infectious diseases was observed. Nowadays, the potential applications of vaccines extend far beyond prevention of infectious diseases, and vaccination is considered to be a most promising weapon against a variety of different conditions. Vaccine safety has been regarded as excellent at the level of the population (1 ), but adverse effects have also been reported (2 ). Concerns about the use of aluminum adjuvants have emerged following (i) recognition of their role at the origin of the so-called macrophagic myofasciitis (MMF) lesion in 2001 (3 , 4 ), which revealed fundamental misconception of their adjuvant effect and pointed out their unexpectedly long-lasting biopersistence (4 ); and (ii) demonstration of their apparent capacity to migrate in lymphoid organs and then disseminate throughout the body within monocyte-lineage cells and progressively accumulate in the brain (5 ). The present paper will review these emerging characteristics of alum adjuvant particles that raise concerns about innocuity of this widely used compound.

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