Monday, October 20, 2014

Doctor treats Ebola successfully with HIV drug in Liberia

* http://edition.cnn.com/2014/09/27/health/ebola-hiv-drug/  

(CNN) - A doctor in rural Liberia inundated with Ebola patients says he's had good results with a treatment he tried out of sheer desperation: an HIV drug.

Dr. Gorbee Logan has given the drug, lamivudine, to 15 Ebola patients, and all but two survived. That's about a 13% mortality rate. Across West Africa, the virus has killed 70% of its victims."

"Doctor treats Ebola with HIV drug in Liberia -- seemingly successfullyA doctor in rural Liberia inundated with Ebola patients says he's had good results with a treatment he tried out of sheer desperation: an HIV drug.

Friday, October 3, 2014

Chalder: 19% recovery from chronic fatigue with CBT, and 15% in CDC defined CFS, a placebo is MORE effective !!

"While 72.2% met the Oxford criteria for CFS at pre-treatment assessment, 53.1% did so at the 6-month follow-up (Pearson chi square = 19.5, df = 1, p < 0.001).

Likewise, chi-square revealed a significant reduction in prevalence from 52.6% of the participants meeting the CDC criteria at the pre-treatment assessment to 37.5% at the 6-month follow-up (Pearson chi square = 16.8, df = 1, p < 0.001).

my PS:  Oxford criteria  = chronic fatigue, not CFS or ME !!
CDC criteria = CFS, not ME !! *

So Chalder admits, CBT is useless !!

@ pubmed:
 2014 Aug 26;63C:1-8. doi: 10.1016/j.brat.2014.08.013. [Epub ahead of print]

Prevalence and predictors of recovery from chronic fatigue syndrome in a routine clinical practice.

Abstract

Cognitive behavioural therapy (CBT) is one of the treatments of choice for patients with chronic fatigue syndrome (CFS). However, the factors that predict recovery are unknown. The objective of this study was to ascertain the recovery rate among CFS patients receiving CBT in routine practice and to explore possible predictors of recovery. Recovery was defined as no longer meeting Oxford or CDC criteria for CFS measured at 6 months follow-up. A composite score representing full recovery additionally included the perception of improvement, and normal population levels of fatigue and of physical functioning. Logistic regression was used to examine predictors of recovery. Predictors included age, gender, cognitive and behavioural responses to symptoms, work and social adjustment, beliefs about emotions, perfectionism, anxiety and depression at baseline. At 6 months follow-up 37.5% of the patients no longer met either the Oxford or the CDC criteria for CFS while 18.3% were fully recovered. Multivariate analyses showed that worse scores on the work and social adjustment scale, unhelpful beliefs about emotions, high levels of depression and older age were associated with reduced odds for recovery. Recovery rates in this routine practice were comparable to previous RCTs. There was a wide spectrum of significant predictors for recovery.
Copyright © 2014 The Authors. Published by Elsevier Ltd.. All rights reserved.

KEYWORDS:

Chronic fatigue syndrome; Cognitive behavioural therapy; Follow-up; Longitudinal; Recovery
PMID:
 
25222752
 
[PubMed - as supplied by publisher]

Professor Wessely: A placebo is MORE effective than CBT‏

Saturday, September 27, 2014

Psycho blah blah from the American P2P



The P2P:

"Conclusions. No current diagnostic tool or method has been dequately tested to identify patients with ME/CFS when diagnostic uncertainty exists. CBT and GET have shown some benefit whereas other interventions have insufficient evidence to guide clinical practice. GET appears to be associated with harms in some patients whereas the negative effects of being given a diagnosis of ME/CFS appear to be more universal."

Jeannette @ http://thoughtsaboutme.com/2014/09/24/p2p-dont-buy-the-hype-protest/

"Engaging the government allows them to claim that they took the community’s concerns into account when they have no intention of doing so. Their outreach to the patient community, the comment period, is a mirage.”

...

"Remember the changes that were made to the IOM panel in response to patients’ concerns about various suggested panel members’ conflict of interests? No? I don’t either. The make-up of the committee was not changed at all despite a few advocates researching the background of the proposed panel members and finding some troubling facts. The feedback of those advocates was entirely ignored. If the government wanted our input, they would have designed the whole process completely differently instead of merely having one token, hand-picked patient advocate at the P2P workshop purporting to speak for the entire community. Giving our input means legitimizing the farce. Don’t fall for it.”

...

"There is no doubt in my mind that P2P will harm patients greatly and I will have no part in that by being seduced into thinking that my engaging will result in any meaningful effect on the process."

...

""P2P: Don’t Buy the Hype! Protest!The reason why I will not cooperate with, or participate or engage in, the P2P process is very simple. HHS and NIH have shown time and time again that they do not have ME patients’ interest at hear...thoughtsaboutme.com

Thursday, September 18, 2014

Damage to the basal ganglia causes fatigue in ME/CFS

@ pubmed:


 2014 May 23;9(5):e98156. doi: 10.1371/journal.pone.0098156. eCollection 2014.

Decreased basal ganglia activation in subjects with chronic fatigue syndrome: association with symptoms of fatigue.

Abstract

Reduced basal ganglia function has been associated with fatigue in neurologic disorders, as well as in patients exposed to chronic immune stimulation. Patients with chronic fatigue syndrome (CFS) have been shown to exhibit symptoms suggestive of decreased basal ganglia function including psychomotor slowing, which in turn was correlated with fatigue. In addition, CFS patients have been found to exhibit increased markers of immune activation. In order to directly test the hypothesis of decreased basal ganglia function in CFS, we used functional magnetic resonance imaging to examine neural activation in the basal ganglia to a reward-processing (monetary gambling) task in a community sample of 59 male and female subjects, including 18 patients diagnosed with CFS according to 1994 CDC criteria and 41 non-fatigued healthy controls. For each subject, the average effect of winning vs. losing during the gambling task in regions of interest (ROI) corresponding to the caudate nucleus, putamen, and globus pallidus was extracted for group comparisons and correlational analyses. Compared to non-fatigued controls, patients with CFS exhibited significantly decreased activation in the right caudate (p = 0.01) and right globus pallidus (p = 0.02). Decreased activation in the right globus pallidus was significantly correlated with increased mental fatigue (r2 = 0.49, p = 0.001), general fatigue (r2 = 0.34, p = 0.01) and reduced activity (r2 = 0.29, p = 0.02) as measured by the Multidimensional Fatigue Inventory. No such relationships were found in control subjects. These data suggest that symptoms of fatigue in CFS subjects were associated with reduced responsivity of the basal ganglia, possibly involving the disruption of projections from the globus pallidus to thalamic and cortical networks.
PMID:
 
24858857
 
[PubMed - in process] 
PMCID:
 
PMC4032274
 
Free PMC Article

Monday, September 15, 2014

Rintatolimod aka Ampligen produces objective improvement in CFS/ME

@ pubmed:

 2012;7(3):e31334. doi: 10.1371/journal.pone.0031334. Epub 2012 Mar 14.

A double-blind, placebo-controlled, randomized, clinical trial of the TLR-3 agonist rintatolimod in severe cases of chronic fatigue syndrome.

Abstract

BACKGROUND:

Chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) is a severely debilitating disease of unknown pathogenesis consisting of a variety of symptoms including severe fatigue. The objective of the study was to examine the efficacy and safety of a TLR-3 agonist, rintatolimod (Poly I: C(12)U), in patients with debilitating CFS/ME.

METHODS AND FINDINGS:

A Phase III prospective, double-blind, randomized, placebo-controlled trial comparing twice weekly IV rintatolimod versus placebo was conducted in 234 subjects with long-standing, debilitating CFS/ME at 12 sites. The primary endpoint was the intra-patient change from baseline at Week 40 in exercise tolerance (ET). Secondary endpoints included concomitant drug usage, the Karnofsky Performance Score (KPS), Activities of Daily Living (ADL), and Vitality Score (SF 36). Subjects receiving rintatolimod for 40 weeks improved intra-patient placebo-adjusted ET 21.3% (p = 0.047) from baseline in an intention-to-treat analysis. Correction for subjects with reduced dosing compliance increased placebo-adjusted ET improvement to 28% (p = 0.022). The improvement observed represents approximately twice the minimum considered medically significant by regulatory agencies. The rintatolimod cohort vs. placebo also reduced dependence on drugs commonly used by patients in an attempt to alleviate the symptoms of CFS/ME (p = 0.048). Placebo subjects crossed-over to receive rintatolimod demonstrated an intra-patient improvement in ET performance at 24 weeks of 39% (p = 0.04). Rintatolimod at 400 mg twice weekly was generally well-tolerated.

CONCLUSIONS/SIGNIFICANCE:

Rintatolimod produced objective improvement in ET and a reduction in CFS/ME related concomitant medication usage as well as other secondary outcomes.

TRIAL REGISTRATION:

ClinicalTrials.gov NCT00215800.
PMID:
 
22431963
 
[PubMed - indexed for MEDLINE] 
PMCID:
 
PMC3303772
 
Free PMC Article

Saturday, September 13, 2014

Friday, September 12, 2014

Severity of symptom flare after moderate exercise is linked to cytokine activity in CFS

White AT, Light AR, Hughen RW, Bateman L, Martins TB, Hill HR, Light KC.Journal Psychophysiology. 2010 Jul 1;47(4):615-24. doi: 10.1111/j.1469-8986.2010.00978.x. Epub 2010 Mar 4.Affiliation
Abstract Chronic fatigue syndrome (CFS) patients often report symptom flare (SF) for >24 h after moderate exercise (post-ex). We hypothesized that SF is linked to increases in circulating cytokines and CD40 Ligand (CD40L). In 19 CFS patients and 17 controls, mental and physical fatigue and pain symptom ratings were obtained together with serum for 11 cytokines and CD40L before and at 0.5, 8, 24, and 48 h post-ex. Before exercise, CFS had lower CD40L (p<.05) but similar cytokines versus controls. In subgroups based on SF at 48 h, high SF patients (n=11) increased in IL-1b
eta, IL-12, IL-6, IL-8, IL-10, and IL-13 (p<.05) 8 h post-ex. Low SF patients (n=8) showed post-ex decreases in IL-10, IL-13, and CD40L, and controls decreased in IL-10, CD40L, and TNFalpha (p<.05). Thus, in CFS, cytokine activity may vary directly with SF, which may explain prior inconsistent findings.
PMID 20230500 [PubMed - indexed for MEDLINE] http://www.ncbi.nlm.nih.gov/m/pubmed/20230500/

Tuesday, August 26, 2014

Reduced NK cell cytotoxic activity in patients with CFS/ME



Characterization of Natural Killer cell phenotypes
in chronic fatigue syndrome/myalgic encephalomyelitis.
J Clin Cell Immunol. 2014. 5: 223. doi:10.4172/2155-9899.1000223
Huth TK, Brenu EW, Nguyen T, Hardcastle SL, Johnston S, Ramos S, Staines DR, Marshall-Gradisnik SM.


Received date: April 22, 2014,
Accepted date: June 7, 2014,
Published date: June 14, 2014


Abstract

Objective:

Natural Killer (NK) cells are classified into different phenotypes
according to the expression of the surface markers CD56 and CD16.

Each NK cell phenotype has a role in the immune response
through cytotoxic activity or cytokine production.

Reduced NK cell cytotoxic activity is a consistent finding
in patients with Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME) and
investigations into the potential causes of reduced NKcell cytotoxic activity
have predominantly focused on total NK cells.

The purpose of this study was
to investigate and characterize four NK cell phenotypes in CFS/ME.


Methods:

Twenty nine CFS/ME patients (mean age ± SEM=48.28 ± 2.63)
meeting the 1994 Fukuda definition
and 27 healthy controls (mean age ± SEM=49.15 ± 2.51)
were included in this study.

Flow cytometric protocols identified
CD56brightCD16-/dim, CD56dimCD16-, CD56dimCD16+ or CD56-CD16+ NK cells
for the measurement of surface markers
including adhesion moleculesCD2, CD18, CD11a, CD11b and CD11c,
natural cytotoxicity receptors, Killer Immunoglobulin Like Receptors,
signalling lymphocytic activation molecules and cell maturation (CD57).

Following stimulation,
NK cell phenotype expression of CD107a and CD107b
was measured as a marker for degranulation.

Intracellular staining measured lytic proteins
including perforin, Granzyme A and Granzyme B
in the four NK cell phenotypes.

Results:


from CFS/ME patients.

from CFS/ME patients was significantly increased.


Conclusion:

This is the first study to characterize
four NK cell phenotypes in CFS/ME
by investigating surface and intracellular molecules
necessary for NK cell effector function.

The data suggests that
a combination of impairments in CD56dimCD16+ NK cells from CFS/ME patients
may contribute to reduced cytotoxic activity of this phenotype.


Keywords:

Natural Killer cell; Phenotypes; Chronic Fatigue Syndrome; Cytotoxic activity;
Adhesion molecules; Degranulation; Granzyme B; Cell maturation





Tuesday, August 12, 2014

Chemical changes in immune cell DNA from ME/CFS patients

@ plosone:
RESEARCH ARTICLE

DNA Methylation Modifications Associated with Chronic Fatigue Syndrome

  • Wilfred C. de Vega,
  •  
  • Suzanne D. Vernon,
  •  
  • Patrick O. McGowan mail

  • Published: August 11, 2014
  • DOI: 10.1371/journal.pone.0104757

Abstract

Chronic Fatigue Syndrome (CFS), also known as myalgic encephalomyelitis, is a complex multifactorial disease that is characterized by the persistent presence of fatigue and other particular symptoms for a minimum of 6 months. Symptoms fail to dissipate after sufficient rest and have major effects on the daily functioning of CFS sufferers. CFS is a multi-system disease with a heterogeneous patient population showing a wide variety of functional disabilities and its biological basis remains poorly understood. Stable alterations in gene function in the immune system have been reported in several studies of CFS. Epigenetic modifications have been implicated in long-term effects on gene function, however, to our knowledge, genome-wide epigenetic modifications associated with CFS have not been explored. We examined the DNA methylome in peripheral blood mononuclear cells isolated from CFS patients and healthy controls using the Illumina HumanMethylation450 BeadChip array, controlling for invariant probes and probes overlapping polymorphic sequences. Gene ontology (GO) and network analysis of differentially methylated genes was performed to determine potential biological pathways showing changes in DNA methylation in CFS. We found an increased abundance of differentially methylated genes related to the immune response, cellular metabolism, and kinase activity. Genes associated with immune cell regulation, the largest coordinated enrichment of differentially methylated pathways, showed hypomethylation within promoters and other gene regulatory elements in CFS. These data are consistent with evidence of multisystem dysregulation in CFS and implicate the involvement of DNA modifications in CFS pathology.

Sunday, July 27, 2014

Danish hero Dr Stig Gerdes

Stig Gerdes response to psychiatrist Per Finnish indklagelse on Medical Ethics Board. 
GOOGLE TRANSLATE
Dear Per Fraulund Sorensen
Secretary for Medical Ethics Board
Thus my answer to Per Fink's complaint against me.
sincerely,
Stig Gerdes
-------------------------------------
Medical Association / Medical Ethics Board
Kristianiagade 12
KD-2100 Copenhagen
Dear Colleagues
Psychiatrist Per Fink (PF), have summoned me for Medical Ethics Board on 24/06/14. Below is my rebuttal to the Sound:
The psychiatrist PF claim that I should have 'whipped' a mood against him and his diagnosis, which is a totally unjustified accusation. I'm talking about the problems I see my patients encounter in the social system.
Now PF has ridden a wave of tailwind for 15 years despite the lack of evidence and despite opposition from the very beginning of the disease groups and patient groups whose physical WHO recognized diseases are included in Functional Disorders (FL).
But now, the resistance gradually grown very large, including with the help of groups on Facebook that makes it possible for people to communicate freely and quickly on the subject. And now counts resistance gradually over 70,000 people and 25 patients groups, [1], [2], [3] so now you can no longer hide the resistance and think that it's just a few 'patient-activists' or some' get sick people '(PF manipulative and insulting term for them), which is behind the resistance.
Politicians who was present at the conciliation of functional disorders 20.5.2014 is also very knowledgeable on the subject now. [4] were asked critical questions across the political spectrum from the City of V to SF and V. Opponents counter many, many citizens and politicians while the Minister of Health at the conciliation very embarrassing only read from the Research Centre for Functional sufferings (FFL) and the National Board of Health letters. But he said at one point: "Why do politicians so much about it when I have not been informed" .. it surprised him apparently. His officers had dressed him very badly on. It was embarrassing to watch.
Opposition to FL is paving the way to the top, which, however, stubbornly maintains the concept, but it is only a matter of time, the number of opponents is growing day by day, and at one point the Minister of Health and the Health Protection Agency surrender because they simply can not defend the concept when the FFL is unable to produce evidence.
The 'patient activists', PF refers is seriously working citizens, most of whom are sensible citizens who are advanced in years. Many have felt the adverse effect of diagnosis FL has on their cases at job centers with psychiatric 'treatment' and the consequent delay of their cases. They are incredibly knowledgeable about FL and FFL and they do not like the concept and its effects, including that there is a recoding of their WHO recognized physical diagnoses for FFLs psychiatric diagnoses, which people regard as an abuse and improper treatment and case management where their legal and human rights are violated.
The so-called 'major activity' on social media, I have not started, it was started, when I came to, and the 'activity', which takes place on FL, takes place solely because many citizens are against the concept - and felt the consequences on your own body.
I do not think my posts are hateful, but informative, and I do not think I harass PF, but I inform about his FL-concept.
I have not yet PF got a link to the article where the BDS patients were alleged to have been described as "quack quack" in Ekstra Bladet, and I am not responsible for what is written in Ekstra Bladet, the articles I have written or seen.
PF says he is not able to comment on a specific patient's case, but that is precisely what PF is doing in this article in Dagens Medicin, 06:06:14.:Http://www.dagensmedicin.dk/ opinion / debate / increase gerdes-is-with-to-escalate conflicts / and this is the article that I answer, which of course must be fair. Also, I have close contact with Karina Hansen (KH) family - as PF does not hiding behind secrecy to avoid answering my criticism.
PF has changed KHS WHO recognized physical diagnosis Myalgic Encephalomyelitis (ME) to a pseudo-psychiatric diagnosis: Pervasive Arousal Withdrawal Syndrome (PAWS).
How could PF claim that there has been no coercion in the case of KH? When you get picked up by 5 police officers against his will, then it is forced. If the patient is not subject to compulsion, so should the family and the other free to visit KH, but they will not be allowed.
Both KHS parents and Rebecca Hansen, President of the ME Association, has tried to visit KH, but were stopped before they came in to her. And the whole case hinges visit, because you can not be allowed to take legal action for KH, unless you can get a power of attorney from her, and it prevents psychiatrists effectively with their visit ban. And the guardian, in my opinion, is granted illegally, will not help with that, then the case is locked. It is an utterly unreasonable case. KHS human rights and the rule of law is violated so thoroughly that a similar precedent has not been seen in Denmark in recent times. The case needs to the extent of a court decision, and I am not alone in thinking. Read lawyer Keld Parbergs speech from consultation on FL. [5]
I make the case for KH at least as accurate as PF (who says he should not mention the matter, but do it anyway) because I work with the young woman's parents.
In addition, KHS mother about a patient's history with the names of the accused doctors, as she believes that the time has come to establish the full truth out. PF can not expect any proprietary notices from the mother's side as she obviously believes that it is a gross abuse has happened across her ME-ill daughter. The letter is not an 'indictment' but a record of actual events seen by parents.
I encourage the Medical Ethics Board to read the parents' letter carefully, because there are violated basic rules of medical ethics activities in this case. Only the lack of compulsory admission paperwork is a crime that should never have taken place. Are the papers, I prefer this item back, but until then I maintain the illegality of this procedure.
We have already seen that the ME patient gets worse by graded exercise, and some have even died in psychiatric compulsory treatment. And when no one can be allowed to visit KH PF and Niels Christensen Balle, then appear PF claims KHS health precisely only as allegations without proof.
In my article in Dagens Medicin, 20:06:14:http://www.dagensmedicin.dk/opinion/debat/fl-er-medicinsk-umoralsk/ I have offered PF to have the matter of KH out of the world by offering a meeting between PF, the parents, legal guardian, the leader of
Hammel Neuro Center, lawyers and myself, but unfortunately it is not received by the PF that instead of working with me have summoned me for Medical Ethics Board. Such a meeting would also reveal KH mode. Why should her parents and family did not visit her?
PF obviously does not want to engage in a dialogue on FL and treatment of KH. But I want to point out that it is not prohibited for physicians to engage other physicians, not secrecy, in a communication about a patient. And I would also point out that it is not illegal to raise money for a lawsuit.
Again and again, and thus also, claiming PF that FFLs scientific articles are available on FFLs website, but it is a 'truth' with modifications, you will find a survey on the page you want to read, so there is a link to it, but you have to the library to see it. And in the articles, there is no evidence that their psychiatric treatments should work on physical illness such. irritable bowel syndrome, whiplash, ME and fibromyalgia. If you request specific studies, for example. about the large percentage of patients with the 4 mentioned diseases FFL has healed, you always get just a reference to the website where you saw themselves lacking in the amount of titles and not readily available articles about psychiatric treatment. One gets the impression that the motto is: Led yourself for what you want to read about and see if you can find it ..
If HPV sufferers are not in danger of having a functional diagnosis, so I do not know what the doctor Marianne Rosendal from FFL and the President of DSAM makes a TV2 reports about the HPV vaccine about a girl who has been injured by the vaccine . It appears clearly in the feature that the HPV vaccine can induce functional modes according to Marianne Rosendal explain how the HPV vaccine "is merely the trigger for something that is already latent in the body" [6]
I would draw attention to § 6 and § 7 of the Medical Association's Code of Ethics, which I do not think that PF meet:
§ 6 "Duty to publication of research results. A doctor should present any research results, both positive and negative, as quickly as possible and professionally responsible manner. The presentation should generally be in the appropriate form for a medical forum before it is announced to the public. "
These were at odds with numerous attempts to obtain documentation of how many of the various annexed physical illnesses, which have succeeded FFL to heal, and perhaps especially where many have failed to FFL cure.
§ 7 "Medical independence, impartiality, etc.. Stk. 1: A doctor should be called upon to guarantee the independence of extraneous interests that could affect the physician's ratings and actions. Physicians should the public be independent of ties to industry or for doctor-patient relationship extraneous interests. "
Free drugs and large sums of money from the Lundbeck Foundation and many, many millions of TrygFonden, I could imagine the impact on PF research. Lundbeck, would like to sell psychotropic drugs, and Tryg Insurance companies that have great pleasure of psychiatric diagnoses that do not trigger health insurance and workers' compensation insurance and Tryg Foundation, which finances the letters that support FFLs interests in functional disorders, for example. TrygFondens Launching a disability pension, Sick, but no diagnosis, 2011 and Functional symptoms and disorders, 2012 and Clinical guidance in general practice, functional disorders, 2013.
That, I think, shows that the FFL and PF is certainly not "independent of ties to industry or for doctor-patient relationship extraneous interests."
The extensive documentation PF claims to be in possession of, can not be found, neither of Central Denmark Region, the Board of Health or the Ministry of Health, and neither of the Capital Region. [7]
I have deep respect for sick people, otherwise I was not a doctor and I am convinced that PF 'treatment' of patients is based on a wrong basis, and I doubt that very many of them become healthy after PF treatment. I still want to see evidence that FL is scientific and evidence-based - I hope the Medical Ethics Board can wring them out of the PF.
PF lose focus when he calls my criticism of "violent attack on a vulnerable group of patients." I do certainly no outcome against patients, I question the PF treatment of physical illnesses.
PF claims that 'my campaign', as he calls it, has created insecurity among his patients. I can with even greater emphasis argue that PF creates insecurity among citizens with chronic physical illnesses across the country, as they are constantly exposed to physical diagnoses converted to psychiatric diagnoses of PF and PF sympathizers, which is also extremely unsafe for followed by only psychiatric treatment - and significant risks for misdiagnosis.
The truth is that consultation, conciliation, many newspaper articles, more than 70,000 opponents of PF Concept and PF responses to my criticism has had a major impact in the population. Disease groups pelvic instability, migraine and hopefully soon tinnitus deleted from the PF list of FL, and it is just the beginning - all patient groups for the WHO recognized physical diseases on the list want to have their disease removed from the PF list.
You can not stop the public debate and freedom of expression, because a group of patients and some physicians prefer to see their self-invented diagnoses elevated to the truth. It is freedom of expression, psychiatrists basically going for. For those wanting to silence critics, including me, but they have no right.
I am convinced that most patients prefer to be open message about their situation and that honesty is the best. One should not "impose a patient information, as this obviously does not want," reads § 3 in medical ethics, which I agree with, but you will continue to meet fierce opposition FL on social media and the opposition will not cease, even if I do not participate in it so that PF mission of trying to silence criticism will not succeed, even if PF wants to spare his patients for it. PF and his patients have to face the world as it is, like everyone else.
PF clinic, in my opinion, must be transformed into a private clinic with "alternative medicine" (for that is what it is when he 'treats' physical illness with psychiatric methods without evidence that it works). Job centers should stop references to the Finance Bill, because it is an assault to refer physically ill people to a psychiatrist if they do not want to. These references are used to draw social cases protracted.
A major problem is that doctors use FL as umbrella diagnoses when they can not find out what the patient suffers. This helps the doctors' diagnostic ability and sharpness is weakened because they accept FL as a sufficient diagnosis, despite the fact that the patient has another condition.
FL saves the health care system for animal studies to diagnose patients with such. chest pain that would otherwise require a considerable amount of research using cardiac specialist tools lung examinations and mammograms, etc., etc. If the patient then later die either acute myocardial infarction, in the lungs or breast cancer, it's just too bad they had the a diagnosis, just the wrong one! The doctor was wrong - it happens. Adverse events .. It is medical ethics and lægemoralsk irresponsible!
See additional documentation here. Article: Functional disorders - The Emperor's New Clothes, (was not included in the Right arrow when the debate on the subject was already in Dagens Medicin):http://funktionellidelse.dk/funktionellelidelser.html
§ 3 pcs. 3 The medical ethics of criticism of colleagues that PF have summoned me to break, reads:
"In making criticism of a colleague's medical establishment should criticism be designed in such a way that the criticism does not create unnecessary insecurity or lack of confidence in patients, relatives or the public. A doctor should not ordinarily given to patients and their relatives make derogatory statements about a colleague's professional qualifications. "
This I think I can refute completely. I do not introduce any derogatory statements about PF professional skills towards my patients. I not mention, recommend or speak against PF treatment towards my patients and I treat obviously not my patients with PF methods.
There is a caveat: "in general". This is an extremely un-common situation. It does not happen often that a psychiatrist obtained with treatments without being able to produce evidence that the treatments work, and which has had such great power of the region that PF has, according to the compulsory detention of KH. And here comes the concept of "in general" into. A doctor ie, an obligation to say no, if he believes that patients exposed to unproven treatment, and he has the right to follow his conscience. If atrocities occur, it is every physician's duty to speak out, therefore this add "in general". I mean, I'm from in a most un-common situation.
I have as a citizen's right to have an opinion and to express myself. What PF wants is to stop criticism of FL and prevent free speech on the subject, which is neither reasonable nor possible.
My reasons are quite simple: I'm more responsible to my Hippocratic Oath, my ethics, my conscience, morals and my patients than to PF and his concept, promoted and disseminated throughout the health care system, where the best of my knowledge do not belong.
My conscience tells me to do what I do in a U-common situation, and if I did not follow my conscience, I would appear false, both to my patients and myself. And as long as PF can not put up with clear-cut evidence for its treatment, so I believe that it is time that the medical profession stand up to this concept, as injuries and violates patients with incorrect diagnoses and treatments.
sincerely,
Medical Stig Gerdes
Danmarksgade 11, 1 TV.
7000 Fredericia
________________________________________
[1] Letter from Hanne Holst Rasmussen and 16 patient organizations:http://www.ft.dk/samling/20121/almdel/suu/bilag/306/1250322.pdf
[2] See attached file when the link has disappeared from the web
[3] See the attached file when the link has disappeared from the web
[4] Link to The consultation on FL:http://www.ft.dk/webtv/video/20131/suu/td.1133594.aspx?as=1
[5] Attorney Keld Pars's speech at the hearing on FL:http://funktionellidelse.dk/hoering1.html
[6] Medical Stig Gerdes, 'symptom researcher' Marianne Rosendal from FFL and the President of DSAM TV2 about the HPV vaccine, FL and FFLs filter theory: https://www.youtube.com/watch?v=WBFykPs92LY
[7] No evidence of FL from Central Denmark Region, the Board of Health or the Ministry of Health: http://funktionellidelse.dk/solidside1.html

Friday, June 27, 2014

Altered Lymphocytes in Chronic Fatigue Syndrome

Authors: Isabel Barao, Ph.D., Daniel Peterson, M.D., Dorothy Hudig, Ph.D;
Presentation format: Oral or Poster
Corresponding author: isilvestre@medicine.nevada.edu
Title: Altered Distribution of Lymphocyte Populations in Chronic Fatigue Syndrome Patients
Authors: Isabel Barao, Ph.D., Daniel Peterson, M.D., Dorothy Hudig, Ph.D
Institutional Affiliations: University of Nevada, Reno, School of Medicine, Simmaron Research, Inc., Sierra Internal Medicine
Key Words: CFS, NK cells, T cells, cytotoxicity, viral infections

Objective: The goal of our research is to define immunologic deficiencies of patients with chronic fatigue syndrome (CFS) and ultimately to improve the health of these patients by increasing their immunity. Setting:CFS is a debilitating disease of unknown cause(s) defined by the Centers for Disease Control and Prevention (CDC) in Atlanta, GA. Our patient population is the well-known Reno-Lake Tahoe CFS cohort. Methods: Peripheral blood is the site of traffic of lymphocytes with varying roles in immunity. Lymphocytes are circulating so as to be available to fight infections anywhere in the body or trafficking into secondary lymphoid organs where the lymphocytes will proliferate and differentiate.There are different types of lymphocytes in the blood [including helper T cells, cytotoxic T cells, T cells, B cells, natural killer (NK), and NK-T cells]. Alterations in these populations from healthy individuals are a hallmark of immune stress. To profile these populations, we used flow cytometry with fluorescent antibodies to identify the different populations of lymphocytes in the peripheral blood of CFS patients. Results: We found unusual increases in a 'hybrid' population of lymphocytes in CFS patients. This population has features of both T cells and NK cells and is normally 1-5% of all lymphocytes but can be as high as 30% in the CFS patients. Interpretation: The results are consistent with altered immunity in CFS patients, particularly altered immune responsesto chronic viral infections. Further characterization, including repeated tests of the same patients, is needed to determine if this unusual population is persistent and to determine if it can mediate cytotoxicity towards virally infected cells.

Tuesday, June 17, 2014

F1 legend Michael Schumacher 'out of coma'

F1 champion Michael Schumacher has left hospital in Grenoble and is no longer in a coma, his family says.
The 45-year-old has been transferred to Lausanne university hospital in Switzerland, officials there say.
Schumacher was placed in a medically induced coma after suffering a severe head injury in a skiing accident in the French Alps on 29 December.
His family thanked people who had sent messages of support, saying: "We are sure it helped him."
They also praised the "excellent job" of medical staff at the hospital in Grenoble, in south-east France.
Doctors had kept the seven-time champion in a coma to help reduce swelling in his brain.

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