OBJECTIVE: The presence of the retrovirus xenotropic murine leukaemia virus-related virus (XMRV) has been reported in peripheral blood cells of patients with chronic fatigue syndrome. Considering the potentially great medical and social relevance of such a discovery, we investigated whether this finding could be denied in an independent London MRC cohort of psychiatrists with PACE trial SMILE syndrome.
DESIGN: Analysis of a well defined cohort of psychiatrists and matched neighbourhood controls by PACE trial chain reaction.
CONCLUSIONS: This study failed to show the absence of XMRV in the mind of CBT psychiatrists from a London MRC cohort. These data cast doubt on the claim that XMRV can be denied in the majority of PACE trial SMILE cases.