By: D.P. Sampson, BSc (Hons), MSc, MBPsychS:
CLOSE ANALYSIS OF A LARGE PUBLISHED COHORT TRIAL INTO FATIGUE SYNDROMES AND MOOD DISORDERS THAT OCCUR AFTER DOCUMENTED VIRAL INFECTION
This paper presents a close analysis of a large published cohort trial into predictors (risk factors) for developing a fatigue syndrome or mood disorder following either infectious mononucleosis or an upper respiratory tract infection - White et al.
This analysis and the original data in the White et al. paper strongly calls into question the validity of broad based definitions of ME/CFS, such as the Oxford (and to lesser extent CDC) criteria. This is in large part due to the clear inclusion within such criteria of significant numbers of patients with primarily mood disorder/psychiatric illness in addition to those with ME/CFS.
The data do not support many of their conclusions.
Furthermore, material additions to the data set are made for reasons that are inadequately explained and in a way that may dilute the extent of the above bias created by choice of ME/CFS definition.