The critical role of Env-induced immunosuppression for retrovirus propagation

Géraldine Schlecht-Loufa,b,1, Martial Renarda,1, Marianne Mangeneya,1, Claire Letzeltera, Aurélien Richauda, Bertrand Ducosa, Isabelle Bouallagaa, and Thierry Heidmanna,2
Correspondence should be addressed. E-mail: heidmann@igr.fr

Edited* by John M. Coffin, Tufts University School of Medicine, Boston, MA, and approved January 6, 2010

In conclusion, our work demonstrates the critical role of Env-induced immunosuppression for retrovirus propagation in vivo and identifies a unique definite target for antiretroviral therapies and vaccine strategies, also characterized in the human T-cell leukemia virus (HTLV) and xenotropic murine leukemia virus-related virus (XMRV) retroviruses, opening unprecedented prospects for the treatment of retroviral diseases. Read the Abstract