David J. Newton a,⁎, Gwen Kennedy a, Kenneth K.F. Chan a, Chim C. Lang b, Jill J.F. Belch a, Faisel Khan a: The central finding of this study is that adult patients with ME/CFS have reduced FMD in the brachial artery and reduced post-occlusive reactive hyperemia in the forearm skin microcirculation.
are both endothelium-mediated via an increase in shear
stress [8,9], and the results therefore lend further support to the hypothesis
that endothelial function is impaired in ME/CFS, both in
large vessels and in the microcirculation.
We believe this is the first
time that vascular endothelial dysfunction has been measured directly in ME/CFS patients,
and these findings build on previous work reporting indirect markers of endothelial dysfunction, such as
increased oxidative stress [4,10], inflammation [5,11] and arterial
stiffness . This evidence collectively points to increased cardiovascular
risk in ME/CFS patients, which is borne out epidemiologically by
their high mortality due to heart disease . Read more>>