Jamie Deckoff-Jones MD:
We have previously reported that most CFS patients are positive for XMRV if multiple detection methods are used.
The development of lymphoid malignancies in 13 of 300 CFS patients suggests that CFS patients are at a several hundred fold increased risk for malignancy compared to generally quoted incidences in the general population.
Of these 13 patients, all that were tested were positive for both XMRV and a clonal gd T-cell expansion.
The greatly increased risk for B-cell malignancy in an XMRV infected population may be due to infection of the B-cell line by XMRV. Cancers have mutated genes and changes in gene expression that could make them permissive to infection by retroviruses. Retroviruses have been thought to cause cancer by insertional mutagenisis.
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