Monday, April 4, 2011

Dr. Dantini on Antivirals for ME/CFS

by Cort on April 3, 2011: Physicians are taught that IgG results have no bearing on whether an infection is active or not but Dr. Dantini, Dr. Lerner and Dr. Montoya. All believe that very high IgG levels in the presence of illness often do reflect an active infection.

Dr. Dantini believes antibody titers about 4 times what is considered normal – reflect an active infection in a person with the symptoms of ME/CFS/FM.

Antibody Normal Dantini – Positive EBV
IgG .91 3.64
EBV IgM .91 3.64
EBV Nuclear Antigen 1:10 1:40
EBV Early Antigen 1:10 1:40
CMV IgG 1.09 1.36 CMV
IgM 1.09 1.36

These doctors diverge from other physicians on duration of antiviral treatment needed to be effective as well. Most herpesvirus infections in the population are quickly staunched using short courses of antivirals. Check out the prescribing information for Valtrex (valacyclovir) for genital herpes (1 gram twice daily for 10 days), herpes zoster (I gram 3/’s daily for 7 days) and CMV retinitis (900 mgs of Valcyte 2x’s/day for 21 days. ).

Most doctors quail at the idea of taking high levels of these drugs for months or a year or longer. Why, they ask, would Valtrex be able to quickly stop a very visible and painful infection but not inhibit a silent one that has no visible effects? Dr Dantini focuses mostly on famciclovir (Famvir) and valacyclovir (Valtrex) and uses ganciclovir (Centovene) and valganciclovir (Valcyte) less, because of their side effects.

He notes that dosage varies but they generally need to be higher than is used to treat fever blisters and genital herpes and he tends to use similar doses to those used to treat herpes zoster (I gram/3′s daily). If there is no response he gradually increases the dosage.

He does not claim to have found the whole answer to FM/CFS but does believe these usually overlooked viruses play a large role. Read more>>

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