Friday, October 28, 2011

Nancy Klimas, Professor of Immunology: two possible theories why Rituximab works in ME / CFS

Jørgen Jelstad:!/DeBortgjemte

Professor of Immunology at the University of Miami, Nancy Klimas, is the one who has worked the longest and most closely with immune problems in ME / CFS for over 25 years, and she looked forward to great results to come.

- I think they do great work. I heard about their work the first time in London for a couple of years ago, and I was very excited. I could hardly wait for them to get this done, says Klimas.

She says she was so excited that she had to watch out not to jump on it even at the risk of stepping Haukeland researchers at the toes.

- But I thought that I had to let them do what they did alone, because they do it right, and they deserve all the credit for the work they do. It is very exciting and very innovative, says Klimas.

She is aware that Rituximab is a "big gun".

- To turn out nearly all B-cells of the immune system. So the question in my mind now is, why it works, says Klimas.

She believes there are two possible theories. One possibility, according to Klimas that a large subset of patients have an autoimmune disease that is maintained by an autoantibody -that is, an antibody directed against its own tissues.

- It is certainly possible, and this drug's use in other autoimmune diseases such as arthritis, says Klimas.

The other possibility is, according to Klimas that B-cells are the reservoir for a virus that has great significance in the disease. B-cells include the main reservoir for ... Read more>>

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