Authors: Sachdeva AK, Kuhad A, Tiwari V, Chopra K.
Affiliation: Pharmacology Research Laboratory, University Institute of Pharmaceutical Sciences, UGC Centre of Advanced Study, Panjab University, Chandigarh-160 014 India.
NLM Citatition: PMID: 19643148
Three decades after the coining of the term chronic fatigue syndrome, the diagnosis of this illness is still symptom based and the aetiology remains elusive. Chronic fatigue syndrome pathogenesis seems to be multifactorial and the possible involvement of immune system is supported.
The present study was designed to evaluate the effects of the epigallocatechin gallate in a mouse model of immunologically-induced chronic fatigue.
On 19th day, after lipopolysaccharide/Brucella abortus administration, the mice showed significant increase in immobility period, post swim fatigue and thermal hyperalgesia. Behavioral deficits were coupled with enhanced oxidative-nitrosative stress as evident by increased lipid peroxidation, nitrite levels and decreased endogenous antioxidant enzymes (superoxide dismutase, reduced glutathione and catalase) and inflammation (increased levels of tumor necrosis factor-alpha and tissue growth factor-beta). Chronic treatment with epigallocatechin gallate restored these behavioral and biochemical alterations in mice.
The present study points out towards the beneficial effect of epigallocatechin gallate in the amelioration of chronic fatigue syndrome and thus may provide a new, effective and powerful strategy to treat chronic fatigue syndrome.
TEENAGER took his own life after struggling to come to terms with having ME/CFS (Myalgic Encephalomyelitis/Chronic Fatigue Syndrome).
The self serving psychiatrists who,for over two decades, have taken all the research & treatment funding for the neurological illness ME should be brought to account for the intense suffering, hopelessness and despair they have caused.
3 comments:
Is this scientific proof that CBT sends you bananas, Dr Speedy? Was there a control group that stayed plums?
Epigallocatechin gallate ameliorates chronic fatigue syndrome in mice: Behavioral and Biochemical Evidence.
Journal: Behav Brain Res. 2009 Jul 27. [Epub ahead of print]
Authors: Sachdeva AK, Kuhad A, Tiwari V, Chopra K.
Affiliation: Pharmacology Research Laboratory, University Institute of Pharmaceutical Sciences, UGC Centre of Advanced Study, Panjab University, Chandigarh-160 014 India.
NLM Citatition: PMID: 19643148
Three decades after the coining of the term chronic fatigue syndrome, the diagnosis of this illness is still symptom based and the aetiology remains elusive. Chronic fatigue syndrome pathogenesis seems to be multifactorial and the possible involvement of immune system is supported.
The present study was designed to evaluate the effects of the epigallocatechin gallate in a mouse model of immunologically-induced chronic fatigue.
On 19th day, after lipopolysaccharide/Brucella abortus administration, the mice showed significant increase in immobility period, post swim fatigue and thermal hyperalgesia. Behavioral deficits were coupled with enhanced oxidative-nitrosative stress as evident by increased lipid peroxidation, nitrite levels and decreased endogenous antioxidant enzymes (superoxide dismutase, reduced glutathione and catalase) and inflammation (increased levels of tumor necrosis factor-alpha and tissue growth factor-beta). Chronic treatment with epigallocatechin gallate restored these behavioral and biochemical alterations in mice.
The present study points out towards the beneficial effect of epigallocatechin gallate in the amelioration of chronic fatigue syndrome and thus may provide a new, effective and powerful strategy to treat chronic fatigue syndrome.
Teenager took his life after suffering years of ill health
http://www.eastbourneherald.co.uk/news/Teenager-took-his-life-after.5513722.jp
TEENAGER took his own life after struggling to come to terms with having ME/CFS (Myalgic Encephalomyelitis/Chronic Fatigue Syndrome).
The self serving psychiatrists who,for over two decades, have taken all the research & treatment funding for the neurological illness ME should be brought to account for the intense suffering, hopelessness and despair they have caused.
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