Antibody to parvovirus B19 nonstructural protein is associated with chronic arthralgia in patients with Chronic Fatigue Syndrome / Myalgic Encephalomyelitis (CFS/ME)
"Parvovirus B19 DNAaemia was documented in 11 CFS patients as compared with none of the controls. In a previous study (Kerr et al, 2001), 4 of 5 patients with B19-associated CFS (ie patients followed from the time of detection of anti B19 IgM whose CFS-like symptom onset occurred comtemporaneously with detection of anti-B19 IgM, and whose symptoms persisted such they later fulfilled diagnostic criteria for CFS) exhibited B19 DNAaemia at follow-up. Therefore, this finding may suggest that the disease in these 11 patients, may have been somehow induced by acute B19 infection. ****Such patients have previously been shown to respond very well to intravenous immunoglobulin (IVIG)****, the only specific treatment for parvovirus B19 infection (Kerr et al, 2003). In patients with antibodies to anti-B19 NS1, but without parvovirus B19 DNAaemia, it is possible that the parvovirus infection was latent and reactivated at a low level."
References from above:
Kerr JR, Barah F, Mattey DL, Laing I, Hopkins SJ, Hutchinson IV, Tyrrell DA. (2001). Circulating tumour necrosis factor-alpha and interferon-gamma are detectable during acute and convalescent parvovirus B19 infection and are associated with prolonged and chronic fatigue. J Gen Virol 82:3011-3019. [TK: This is available on the CFS Research Foundation's publications webpage: http://www.cfsrf.com/Publications.htm - direct address: http://www.cfsrf.com/pdf/JGV.pdf ]
Kerr JR, Cunniffe VS, Kelleher P, Bernstein RM, Bruce IN. (2003). Successful intravenous immunoglobulin (IVIG) therapy in parvovirus B19-associated chronic fatigue syndrome (CFS). Clin Infect Dis 36:e100-6. [TK: This is available on the CFS Research Foundation's publications webpage: http://www.cfsrf.com/Publications.htm - direct address: http://www.cfsrf.com/pdf/ivig.pdf]
-------comment from Tom Kindlon, Irish ME Association:-------- Reminder that there were in total 200 patients with "CFS/ME" from the US and UK in this study.
This would mean that 11/200=5.5% of CFS patients on average would have Parvovirus B19 DNAaemia that could be found by testing at follow-up (i.e. testing at the start of the illness isn't required) and be prime candidates for intravenous immunoglobulin (IVIG)
As mentioned above, the 2001 study found that 4/5 (=80%) of those with parvovirus B19-associated CFS exhibited B19 DNAaemia at follow-up. [In the 2001 study, the 39 patients with parvovirus who were followed were contacted after a follow-up period of 2-37 months (mean of 22 +/- 5 months)]. In the 2009 paper, the mean duration of illness for the whole sample was 3.67 years or 44 months.
If it was the same rate at 3.67 years, a further 5.5%/4=1.375% would be candidates for intravenous immunoglobulin (IVIG) (on top of the aforementioned 5.5%) as their illness would have started with Parvovirus B19 (i.e. it would appear that 6.875% of cases of CFS started with Parvovirus B19).
If the rate at 3.67 years went down to 60% (say - random figure less than 80% chosen as being less than 80), a further (5.5%/60)*40=3.67% would be candidates for intravenous immunoglobulin (IVIG) (on top of the aforementioned 5.5%) as their illness would have started with Parvovirus B19 (i.e. that would give a figure of 9.17% of cases of CFS started with Parvovirus B19).
New medical research, relating to M.E. (myalgic encephalomyelitis) and the XMRV virus, have shattered the MRC belief that M.E. is a psychiatric condition.
The Chief Medical Officer( CMO) and MRC have for many decades adhered to the idea that these patients could be lined up as a psychiatric problem.
Certain British psychiatrists used this notion for their own self interest in obtaining government research grants and conflict of interest payment from disability insurance companies.
The recent M.E. research is not necessarily related to the resignation of Sir Liam Donaldson from the post of Chief Medical Officer(CMO) together with the resignation of the chief executive of the Medical Research Council, Sir Leszek Borysiewicz.
These resignations however give the present or next government a chance to clean house.
Both these gentlemen have failed the thousands of patients who suffer from myalgic encephalomyelitis (M.E.), not only failed to recognize their disease but have gone one step further and labeled them as psychotic or neurotic.
They have thus been deprived of proper treatment and relegated to a psychological cognitive training or worse still a Graded Exercise Therapy (GET), both of which are defined in medical literature as useless and in some cases dangerous.
Both these gentlemen failed to react or examine the motives of psychiatrists promoting these methods.
M.E. is a physical disease and British Medical establishment must recognize the fact and underwrite proper research rather that promote useless psychiatric methods.
3 comments:
What a puzzle for the Citrus-Banana Therapist to sort out, Dr Speedy
Do the bananas have an aberrant orange belief
- or do the oranges have an aberrant banana belief?
Thankfully the MRC will grant a taxpayers' millions for a FINE trial -`Fruit Identity Nonsensical Inquiry
and a PACE trial - Pineapples Are Confusing Examination
Prof VeryPointyend will be paring down the evidence
Antibody to parvovirus B19 nonstructural protein is associated with chronic arthralgia in patients with Chronic Fatigue Syndrome / Myalgic Encephalomyelitis (CFS/ME)
"Parvovirus B19 DNAaemia was documented in 11 CFS patients as compared with
none
of the controls. In a previous study (Kerr et al, 2001), 4 of 5 patients
with B19-associated
CFS (ie patients followed from the time of detection of anti B19 IgM whose
CFS-like
symptom onset occurred comtemporaneously with detection of anti-B19 IgM, and
whose
symptoms persisted such they later fulfilled diagnostic criteria for CFS)
exhibited B19
DNAaemia at follow-up. Therefore, this finding may suggest that the disease
in these 11
patients, may have been somehow induced by acute B19 infection. ****Such
patients have
previously been shown to respond very well to intravenous immunoglobulin
(IVIG)****, the
only specific treatment for parvovirus B19 infection (Kerr et al, 2003). In
patients with
antibodies to anti-B19 NS1, but without parvovirus B19 DNAaemia, it is
possible that the
parvovirus infection was latent and reactivated at a low level."
References from above:
Kerr JR, Barah F, Mattey DL, Laing I, Hopkins SJ, Hutchinson IV, Tyrrell DA.
(2001). Circulating tumour necrosis factor-alpha and interferon-gamma are
detectable
during acute and convalescent parvovirus B19 infection and are associated
with
prolonged and chronic fatigue. J Gen Virol 82:3011-3019.
[TK: This is available on the CFS Research Foundation's publications
webpage: http://www.cfsrf.com/Publications.htm - direct address:
http://www.cfsrf.com/pdf/JGV.pdf ]
Kerr JR, Cunniffe VS, Kelleher P, Bernstein RM, Bruce IN. (2003). Successful
intravenous immunoglobulin (IVIG) therapy in parvovirus B19-associated
chronic fatigue
syndrome (CFS). Clin Infect Dis 36:e100-6.
[TK: This is available on the CFS Research Foundation's publications
webpage: http://www.cfsrf.com/Publications.htm - direct address:
http://www.cfsrf.com/pdf/ivig.pdf]
-------comment from Tom Kindlon, Irish ME Association:--------
Reminder that there were in total 200 patients with "CFS/ME" from the US and
UK in this study.
This would mean that 11/200=5.5% of CFS patients on average would have
Parvovirus B19 DNAaemia that could be found by testing at follow-up (i.e.
testing at the start of the illness isn't required) and be prime candidates
for intravenous immunoglobulin (IVIG)
As mentioned above, the 2001 study found that 4/5 (=80%) of those with
parvovirus B19-associated CFS exhibited B19
DNAaemia at follow-up. [In the 2001 study, the 39 patients with parvovirus
who were followed were contacted after a follow-up period of 2-37 months
(mean of 22 +/- 5 months)]. In the 2009 paper, the mean duration of illness
for the whole sample was 3.67 years or 44 months.
If it was the same rate at 3.67 years, a further 5.5%/4=1.375% would be
candidates for intravenous immunoglobulin (IVIG) (on top of the
aforementioned 5.5%) as their illness would have started with Parvovirus B19
(i.e. it would appear that 6.875% of cases of CFS started with Parvovirus
B19).
If the rate at 3.67 years went down to 60% (say - random figure less than
80% chosen as being less than 80), a further (5.5%/60)*40=3.67% would be
candidates for intravenous immunoglobulin (IVIG) (on top of the
aforementioned 5.5%) as their illness would have started with Parvovirus B19
(i.e. that would give a figure of 9.17% of cases of CFS started with
Parvovirus B19).
23 Dec 2009
Dear Prime Minister
New medical research, relating to M.E. (myalgic
encephalomyelitis) and the XMRV virus, have
shattered the MRC belief that M.E. is a psychiatric
condition.
The Chief Medical Officer( CMO) and MRC have for
many decades adhered to the idea that these
patients could be lined up as a psychiatric problem.
Certain British psychiatrists used this notion for their
own self interest in obtaining government research
grants and conflict of interest payment from
disability insurance companies.
The recent M.E. research is not necessarily related
to the resignation of Sir Liam Donaldson from the
post of Chief Medical Officer(CMO) together with the
resignation of the chief executive of the Medical
Research Council, Sir Leszek Borysiewicz.
These resignations however give the present or next
government a chance to clean house.
Both these gentlemen have failed the thousands of
patients who suffer from myalgic encephalomyelitis
(M.E.), not only failed to recognize their disease but
have gone one step further and labeled them as
psychotic or neurotic.
They have thus been deprived of proper treatment
and relegated to a psychological cognitive training or
worse still a Graded Exercise Therapy (GET), both of
which are defined in medical literature as useless
and in some cases dangerous.
Both these gentlemen failed to react or examine the
motives of psychiatrists promoting these methods.
M.E. is a physical disease and British Medical
establishment must recognize the fact and
underwrite proper research rather that promote
useless psychiatric methods.
Yours Sincerely
Dr Derek Enlander
New York
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