Post-exercise acid exposure 50 times higher in ME/CFS patients vs healthy controls, with no reduction with repeat exercise

Tom Kindlon:

Date: Thu, 30 Jun 2011 23:20:55 +0100
Reply-To: Tom Kindlon <[log in to unmask]>
Sender: ME/CFS and Fibromyalgia Information Exchange Forum
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From: Tom Kindlon <[log in to unmask]>
Subject: Re: RES: LOSS OF CAPAC ITY TO RECOVER FROM ACIDOSIS ON RE PEAT
EXERCISE IN CHRONIC FATI GUE SYNDROME – A
CASE CONTROL S TUDY
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Here's a nice/interesting quote:
Total post-exercise acid exposure c.50 times higher in #cfs patients vs healthy controls http://t.co/PkMAYbH #mecfs

"Using this approach, *****total post-exercise acid exposure is of the order
of 50-fold higher in CFS patients exercising to the same degree as normal
controls*****, with no reduction in this pattern of sustained high level
acidosis with repeat exercise. We believe that the local and systemic
sequelae of this sustained acid exposure contribute significantly to the
expression of fatigue in CFS."

From this paragraph:

There are aspects of the abnormality in acid homeostasis in CFS which differ
to those seen in PBC and which may significantly contribute to the severity
of fatigue in CFS. We have previously reported that when PBC patients
undergo repeat exercise the degree of acidosis seen within muscle reduces
with each exercise episode, suggesting the retention of some compensatory
capacity for excess muscle acidosis in PBC (28). One mechanism for this is
increase in proton flux, and the speed of onset of maximum proton excretion,
with repeat exercise. This phenomenon, which is also a feature of
mitochondrial disease where increased proton efflux after exercise helps
compensate for reduced aerobic capacity [35], was absent from the CFS
patients. These findings suggest that CFS patients are unable to compensate
for the increased reliance upon anaerobic energy sources during muscle
contraction in comparison to other conditions with reduced aerobic capacity.
The net effect of these combined effects can be seen in terms of cumulative
acid exposure determined from the area under the curve for pH. Using this
approach total post-exercise acid exposure is of the order of 50-fold higher
in CFS patients exercising to the same degree as normal controls, with no
reduction in this pattern of sustained high level acidosis with repeat
exercise. We believe that the local and systemic sequelae of this sustained
acid exposure contribute significantly to the expression of fatigue in CFS.


http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2362.2011.02567.x/abstract

LOSS OF CAPACITY TO RECOVER FROM ACIDOSIS ON REPEAT EXERCISE IN
CHRONIC FATIGUE SYNDROME – A CASE CONTROL STUDY

David EJ Jones MD PhD1,†, Kieren G Hollingsworth PhD1,2,†, Djordje G
Jakovljevic PhD3,4,5, Gulnar Fattakhova MD3,4, Jessie Pairman3,4,
Andrew M Blamire PhD1,2, Michael I Trenell PhD1,4,5,‡, Julia L Newton
MD PhD3,4,‡

European Journal of Clinical Investigation © 2011 DOI:
10.1111/j.1365-2362.2011.02567.x

See also: The main characteristic of ME is an abnormally delayed muscle recovery after doing trivial things, if you don't have that, you don't have ME
See also: PACE trial's Prof Peter White: Exercise causes Immunological damage in Chronic Fatigue Syndrome and is NOT safe