Jeremy A Garson , Paul Kellam and Greg J Towers:
Retrovirology 2011, 8:13doi:10.1186/1742-4690-8-13
Published: 25 February 2011
Abstract (provisional)
XMRV is a gammaretrovirus associated in some studies with human prostate cancer and chronic fatigue syndrome. Central to the hypothesis of XMRV as a human pathogen is the description of integration sites in DNA from prostate tumour tissues. Here we demonstrate that 2 of 14 patient-derived sites are identical to sites cloned in the same laboratory from experimentally infected DU145 cells. Identical integration sites have never previously been described in any retrovirus infection.
We propose that the patient-derived sites are the result of PCR contamination. This observation further undermines the notion that XMRV is a genuine human pathogen.
My Note: "We propose that the patient-derived sites are the result of PCR contamination." Means that they are not sure ...
See also: Mr Towers, XMRV class viruses do integrate into the same sites repeatedly by Gerwyn Morris, (26 February 2011) PA institute
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