Wednesday, March 2, 2011

Authenticity of XMRV integration sites

By Professor Racaniello:

Integration of retroviral DNA into the cellular genome is essential for the production of new infectious particles.

A strong argument that the novel human retrovirus XMRV is not a laboratory contaminant is the finding that viral DNA is integrated in chromosomal DNA of prostate tumors.

Nucleotide sequence analyses of 14 integration sites in prostate tumor DNAs from 9 different patients previously revealed the expected viral sequences linked to human DNA. But two of these integration sites are identical to those found in a prostate tumor cell line infected with XMRV. Read more>>

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