Thursday, March 10, 2011

Prof Wessely's Investigation into the Presence of XMRV in so called CFS Patients, Gold standard CULTURE NOT done

Otto Erlwein1, Mark J. Robinson1, Steve Kaye1, Gillian Wills1, Shozo Izui2, Simon Wessely3, Jonathan Weber1, Anthony Cleare3, David Collier4, Myra O. McClure1:

1 Jefferiss Research Trust Laboratories, Section of Infectious Diseases, Wright-Fleming Institute, Faculty of Medicine, Imperial College London, London, United Kingdom, 2 Department of Pathology and Immunology, Faculty of Medicine, University of Geneva, Geneva, Switzerland, 3 Department of Psychological Medicine, Institute of Psychiatry, King's College London, Camberwell, London, United Kingdom, 4 Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King's College London, London, United Kingdom

The novel human gammaretrovirus xenotropic murine leukemia virus-related virus (XMRV), originally described in prostate cancer, has also been implicated in chronic fatigue syndrome (CFS). When later reports failed to confirm the link to CFS, they were often criticised for not using the conditions described in the original study. Here, we revisit our patient cohort to investigate the XMRV status in those patients by means of the original PCR protocol which linked the virus to CFS. In addition, sera from our CFS patients were assayed for the presence of xenotropic virus envelope protein, as well as a serological response to it. The results further strengthen our contention that there is no evidence for an association of XMRV with CFS, at least in the UK.

Patients were interviewed using a semi-structured interview [18]; all included patients met the CDC international consensus criteria for CFS.

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My Note: the CDC international consensus criteria to select depression and EXCLUDE CFS Patients

See also: Norwegians to study XMRV in severe ME/CFS with the WPI !! or See also: Is severe ME/CFS caused by an ongoing retrovirus infection ?

PS note: Study Received: November 26, 2010; Accepted: January 26, 2011; Published: March 9, 2011 which is unusually long for a Wesselian study !!

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